Stability Indicating Hplc Method for Ribavirin and its Pharmaceutical Dosage Forms

The present work describes a specific, stability indicating HPLC method for determination of Ribavirin (1) and its pharmaceutical dosage forms.

Ribavirin was chromatographed on a microbondapak C18 column utilizing a simple mixture of 0.01M dibasic potassium phosphate and methanol (95: 5). The detection was done at 207 nm.

The available literature was scanned to locate the various methods(2,3) available along with the one reported in USP XXII.

A comparative study was made of the proposed method and USP method and the advantages over the USP method have been discussed.

The low value of Relative standard deviation and recovery of the drug in the range of 99.1% to 101.5% indicates a good precision and non-interference of the method.