Sustained Release Suppository of Sodium Diclofenac: use of Water Absorbable Polymer |
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Authors: | Toshiaki Nishihata Ayumi Tsutsumi Chie Ikawa Kiyoshi Sakai |
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Affiliation: |
a Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas, USA
b Osaka University of Pharmaceutical Sciences, Osaka, Japan |
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Abstract: | The investigation on the usefulness of water absorbable polymer (Poys® SA-20) for the preparation of sustained release suppository was performed. To prepare the sustained release suppository, sodium diclofenac solution is absorbed into the sphere polymer, and the particles of the polymer after dryness are suspended in the melted triglyceride suppository base, followed by solidification. The sustained release of sodium diclofenac from the suppository was confirmed by the in vitro release study with slow release of sodium diclofenac and by the in vivo absorption study in dogs with an avoidance of transient high plasma diclofenac concentration and a prolong of plasma diclofenac concentration. |
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Keywords: | |
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