| 头孢匹罗的合成 |
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| 引用本文： | 程冬萍,于文博,夏成才,颜继忠. 头孢匹罗的合成[J]. 应用化工, 2006, 35(3): 183-184 |
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| 作者姓名： | 程冬萍 于文博 夏成才 颜继忠 |
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| 作者单位： | 浙江工业大学,药学院,浙江,杭州,310014 |
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| 摘 要： | 丙炔胺和环戊酮在无水乙醇中回流反应5 h生成2,3-环戊烯并吡啶,收率55%。7-氨基头孢烷酸和2-甲氧亚氨基-2-(2-氨基-4-噻唑基)-(z)-硫代乙酸苯胼噻唑酯(AE活性酯)发生酰化反应生成头孢噻肟酸,收率90%。在三甲基碘硅烷作用下,头孢噻肟酸与2,3-环戊烯并吡啶反应,生成头孢匹罗,收率65%1。H NMR对产物及中间体进行了鉴定。
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| 关 键 词： | 头孢匹罗 丙炔胺 2,3-环戊烯并吡啶 AE活性酯 合成 |
| 文章编号： | 1671-3206(2006)03-0183-02 |
| 收稿时间： | 2006-02-15 |
| 修稿时间： | 2006-02-15 |
Synthesis of cefpirome |
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| CHENG Dong-ping,YU Wen-bo,XIA Cheng-cai,YAN Ji-zhong. Synthesis of cefpirome[J]. Applied chemical industry, 2006, 35(3): 183-184 |
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| Authors: | CHENG Dong-ping YU Wen-bo XIA Cheng-cai YAN Ji-zhong |
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| Affiliation: | College of Pharmaceutical, Zhejiang University of Technology, Htmgzhou 310014, China |
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| Abstract: | 2,3-Cyclopentenopyridine was prepared by reaction of cyclopentanone and propargylamine in absolute ethanol,refluxing 5 h,the yield was 55%.Cefotaxime acid was synthesized by 7-ACA and AE active ester,the yield was 90%.Then,in the presence of trimethyliodosiliane,cefpirome was obtained through the reaction of cefotaxime acid and 2,3-cyclopentenopyridine,the yield was 65%.The structure of target substance and intermediate were determined by ~1H NMR. |
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| Keywords: | cefpirome propargylamine 2 3-cyclopentenopyridine AE active ester synthesis |
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