| 4-芳基二氢喹啉酮的合成研究 |
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| 引用本文： | 许晨诗,张洪伟,王文智,张丽娟. 4-芳基二氢喹啉酮的合成研究[J]. 精细化工中间体, 2012, 42(6) |
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| 作者姓名： | 许晨诗 张洪伟 王文智 张丽娟 |
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| 作者单位： | 沈阳药科大学制药工程学院,辽宁沈阳,110016 |
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| 摘 要： | 邻乙氧基苯甲醛与丙二酸经克脑文格尔缩合再与3,4-亚甲二氧基苯胺形成酰胺,最后在三氟乙酸催化下环合生成目标化合物,总收率50.1%。目标化合物经MS和1H NMR确证。改进后的合成路线具有反应条件温和、操作简便、收率高等优点。
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| 关 键 词： | 二氢喹啉酮 肝癌 合成 |
Synthesis of 4-Aryl-3,4-dihydro-2 (1H)-quinolinone |
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| XU Chen-shi , ZHANG Hong-wei , WANG Wen-zhi , ZHANG Li-juan. Synthesis of 4-Aryl-3,4-dihydro-2 (1H)-quinolinone[J]. Fine Chemical Intermediates, 2012, 42(6) |
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| Authors: | XU Chen-shi ZHANG Hong-wei WANG Wen-zhi ZHANG Li-juan |
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| Affiliation: | XU Chen-shi ZHANG Hong-wei WANG Wen-zhi ZHANG Li-juan |
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| Abstract: | The title compound was synthesized starting from O-ethoxybenzaldehyde and malonic acid via Knoevenagel reaction,followed by amidation with 3,4-methylenedioxyphenylamine and cyclization under catalysis of trifluoroacetic acid.The overall yield of the target product reached 50.1% and the structure was confirmed with MS,IR and 1H NMR.This route has advantages of mild reaction conditions,simple procedures and high yield. |
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| Keywords: | 3,4-dihydro-2-quinolinone liver cancer synthesis |
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