| 一步法合成对-(四氢-2H-吡喃-2-氧基)苯酚 |
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| 引用本文： | 冯柏成,李文祺. 一步法合成对-(四氢-2H-吡喃-2-氧基)苯酚[J]. 精细化工中间体, 2012, 42(6) |
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| 作者姓名： | 冯柏成 李文祺 |
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| 作者单位： | 青岛科技大学化工学院,山东青岛,266042 |
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| 摘 要： | 以对苯二酚为原料,在吡啶对甲苯磺酸盐催化下,与3,4-二氢-2H-吡喃一步反应生成对-(四氢-2H-吡喃-2-氧基)苯酚。通过单因素实验确定了反应的适宜条件:以二氯甲烷为溶剂,原料配比n(対苯二酚)∶n(3,4-二氢-2H-吡喃)=2.5∶1,反应温度16±1℃,反应时间3 h。反应的总收率约为19.2%,目标化合物的纯度为99.8%。目标产物的结构通过LC-MS和1H NMR确证。
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| 关 键 词： | 脱氧熊果苷 吡啶对甲苯磺酸盐 一步法合成 |
One Step Synthesis of 4-[(Tetrahydro-2H-pyran-2-yl)oxy]phenol |
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| FENG Bai-cheng , LI Wen-qi. One Step Synthesis of 4-[(Tetrahydro-2H-pyran-2-yl)oxy]phenol[J]. Fine Chemical Intermediates, 2012, 42(6) |
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| Authors: | FENG Bai-cheng LI Wen-qi |
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| Affiliation: | FENG Bai-cheng LI Wen-qi |
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| Abstract: | 4-[(Tetrahydro-2H-pyran-2-yl)oxy]phenol was synthesized in 19.2% yield by the reaction of hydroquinone with 3,4-dihydro-2H-pyran catalyzed by PPTS in dichloromethane.The optimum reaction conditions were as follows: the molar ratio of hydroquinone to 3,4-dihydro-2H-pyran 2.5 to 1,reaction temperature 16℃,reaction time 3 h.The structure of the target compound(99.8%) was determined by means of LC-MS and 1H NMR spectra. |
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| Keywords: | 4-[(tetrahydro-2H-pyran-2-yl)oxy]phenol PPTS one step synthesis |
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