Synthesis, Structural Characterization, and Preliminary Biological Characterization of Organotin Polyethers Derived from Hydroquinone and Substituted Hydroquinones |
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| Authors: | Girish Barot Michael R Roner Yoshinobu Naoshima Kazutaka Nagao Kimberly Shahi Charles E Carraher Jr |
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| Affiliation: | (1) Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA;(2) Florida Center for Environmental Studies, Palm Beach Gardens, FL 33410, USA;(3) Department of Biology, University of Texas Arlington, Arlington, TX 76010, USA;(4) Department of Computer Simulation, Okayama University of Science, Okayama 700-0005, Japan;(5) Research Institute of Technology, Okayama University of Science, Okayama 700-0005, Japan |
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| Abstract: | A variety of dibutyltin polyethers have been synthesized employing the interfacial polymerization technique. The products
are polymers with degrees of polymerization ranging from 60 to 390. Infrared spectral and mass spectral results are consistent
with the proposed structure. The products show good inhibition of a variety of cancer cells including those associated with
bone, breast, prostrate, and lung cancers. Some also show good viral inhibition of the HSV-1 (herpes simplex) and Vaccina
(small pox) viruses with those derived from electron rich hydroquinone derivative being most active. Hydroquinone-derived
polymers containing electron withdrawing groups exhibit inhibition of a variety of gram positive and gram negative bacteria. |
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| Keywords: | Organotin polyethers Dibutyltin polyethers Cancer Viruses Interfacial polymerization Herpes simplex Small pox Bacterial inhibition |
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