分散固相萃取-气相色谱-三重四极杆串联质谱法同时测定沙拉酱中3种防腐剂

建立气相色谱-三重四极杆串联质谱（GC-MS/MS）法同时测定沙拉酱中的3种防腐剂（山梨酸、脱氢乙酸、苯甲酸）的方法。对样品前处理条件的提取方式、涡旋时间、萃取溶剂进行优化，通过分散固相萃取技术净化后，采用气相色谱-三重四极杆串联质谱仪（GC-MS/MS）进行测定，外标法定量。结果表明，3种防腐剂在0.001～0.100 mg/L质量范围内呈现良好的线性关系，相关系数R2均>0.999，回收率为88.6%～104.8%，精密度试验结果相对标准偏差（RSD）为2.0%～5.3%，方法检出限为0.002～0.010 mg/kg，定量限为0.006～0.030 mg/kg。该方法操作简单、灵敏度高、抗干扰能力强、结果准确可靠，可作为沙拉酱中多种防腐剂的测定方法。

Simultaneous determination of 3 preservatives in salad dressing based on dispersive solid phase extraction-gas chromatography-triple quadrupole tandem mass spectrometry

A method of gas chromatography-triple quadrupole tandem mass spectrometry (GC-MS/MS) was established for simultaneous detection of 3 preservatives (sorbic acid, dehydroacetic acid and benzoic acid) in salad dressing. The pre-treatment conditions of extraction method, vortex time and extracting solvent were optimized. After purification by dispersive solid phase extraction (DSPE), the samples were determined by GC-MS/MS and quantified by external standard method. The results showed that the 3 preservatives showed a good linear relationship in the range of 0.001-0.100 mg/L, the correlation coefficients R2 were all higher than 0.999, the recoveries were 88.6%-104.8%, and the relative standard deviations (RSD) of precision test results were 2.0%-5.3%. The detection limit of the method was 0.002-0.010 mg/kg, and the quantification limit was 0.006-0.030 mg/kg. The method was simple, sensitive, anti-interference, accurate and reliable, and could be used as a method for the determination of various preservatives in salad dressing.