Controlled release of 5-aminosalicylic acid from a new pH responsive polymer derived from tamarind seed polysaccharide,acrylic acid,and polyamidoamine |
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| Authors: | R K Dey G S Tiwary Tanushree Patnaik Usha Jha |
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| Affiliation: | (1) Post Graduate Department of Chemistry, Ravenshaw University, Cuttack, 753 003, Orissa, India;(2) Department of Applied Chemistry, Birla Institute of Technology, Mesra, Ranchi, 835 215, India |
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| Abstract: | A new pH-responsive polymer (TKP–AA–PAA) was synthesized from the combination of tamarind kernel powder (TKP), acrylic acid
(AA), and polyamidoamine (PAA) which was utilized for controlled release of 5-aminosalicylic acid (5-ASA) in buffer medium.
The network structure of TKP–AA–PAA was obtained by irradiating the mixture of TKP, AA, and PAA in different proportion in
presence of 2,2-dimethoxy-2-phenyl acetophenone as a photoinitiator. The dynamic and equilibrium swelling properties of the
polymeric materials were studied as a function of pH and time in different buffer solutions similar to that of gastric and
intestinal fluids. The controlled release kinetics of 5-ASA in simulated body fluid showed a Fickian diffusion behavior. |
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