177Lu-DOTATATE治疗神经内分泌瘤患者对环境辐射安全的研究进展

神经内分泌肿瘤是一种起源于分布全身的神经内分泌细胞的肿瘤。¹⁷⁷Lu-DOTATATE已被证明可以显著延长患者无进展生存期，在国外得到了广泛的应用。国外对¹⁷⁷Lu-DOTATATE治疗的辐射安全方面已有较多的研究。国内暂无同类产品上市，且无辐射安全方面的研究，缺少相关的国家标准。本文对近年来国外¹⁷⁷Lu-DOTATATE治疗中与辐射安全相关的研究、法规及管理要求等方面资料进行分析和综述，以期为我国¹⁷⁷Lu-DOTATATE治疗的辐射安全管理规范和标准的制定提供参考。

Research Progress of 177Lu-DOTATATE in the Treatment of Neuroendocrine Tumor Patients with Environmental Radiation Safety

Neuroendocrine tumors (NENs) are rare tumors arising from neuroendocrine cells distributed throughout the body. ¹⁷⁷Lu-DOTATATE has been shown to significantly prolong the progression-free survival of patients, and has been widely used abroad. There are many studies on the radiation safety of ¹⁷⁷Lu-DOTATATE treatment abroad. There are no similar products on the market in China, and there is no research on radiation safety, and there is a lack of relevant national standards. This paper analyzes and summarizes the research, regulations and management requirements related to radiation safety in ¹⁷⁷Lu-DOTATATE treatment abroad in recent years, so as to provide reference for the formulation of radiation safety management norms and standards for ¹⁷⁷Lu-DOTATATE treatment in China.