光学相干层析术无损检测血糖的测量效果评价

为改进现有光学相干层析术(OCT)无损检测血糖评价方法的不足,提出将OCT信号斜率相对变化量和相对标准误差相结合来评价测量结果,并同时得到血糖的理论测量精度。首先,分析了OCT系统共焦函数对测量结果的影响及OCT信号斜率相对误差的计算方法,然后,通过对3只新西兰白兔进行活体实验来评价OCT无损检测血糖的测量结果。在测量血糖引起的OCT信号斜率相对变化量的同时,对OCT信号斜率相对误差也进行了计算,从而获得血糖的理论测量精度。新西兰白兔活体实验表明,线性度较好的拟合区间下OCT信号斜率相对变化量和相对误差分别为(3.7%)/mmol和0.068,(3.4%)/mmol和0.026,(0.93%)/mmol和0.019,血糖理论测量精度分别为±3.7 mmol,±1.5 mmol和±4.1 mmol。OCT信号斜率的相对变化量和相对标准误差相结合的评价方法能更有效地提高血糖理论测量精度,而且拟合区间越大,血糖的测量精度越高。

Evaluation of non-invasive detection of blood glucose using OCT

To improve the evaluation method of non-invasive detection of blood glucose by Optical Coherence Tomography(OCT), a method combining the relative variance of OCT signal slope with the relative standard error was presented to evaluate the measurement effect and to obtain the theoretical precision of blood glucose detection. Firstly, the effect of the OCT confocal function on the blood glucose detection and the computing method of the relative error of OCT signal slope were given. Then, the relative variance and standard error of the OCT signal slope via a vivo experiment on 3 New Zealand rabbits were carried out to evaluate the non-invasive detection of blood glucose. Obtained results indicate that the relative variance and standard error of OCT signal slope are (3.7 %)/mmol & 0.068,(3.4 %)/mmol & 0.026,(0.93 %)/mmol & 0.019, respectively,and the theoretical measuring precision of blood glucose detection are ±3.7 mmol,±1.5 mmol and ±4.1 mmol,respectively. It concludes that the the evaluation method of combining the relative variance and standard error of OCT signal slope can greatly improve the theoretical measuring precision of blood glucose detection,and the larger the fitting interval is,the higher the measuring precision is.