Novel Poly(3-hydroxyoctanoate)/Poly(3-hydroxybutyrate) blends for medical applications |
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| Authors: | P. Basnett K.Y. Ching M. Stolz J.C. Knowles A.R. Boccaccini C. Smith I.C. Locke T. Keshavarz I. Roy |
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| Affiliation: | 1. Department of Applied and Molecular Biosciences, School of Life Sciences, University of Westminster, 115 New Cavendish Street, London W1W 6UW, UK;2. Department of Biomedical Sciences, School of Life Sciences, University of Westminster, 115 New Cavendish Street, London W1W 6UW, UK;3. National Centre for Advanced Tribology at Southampton (nCATS), Engineering Sciences, Lanchester Building, Room 4077, University of Southampton, Southampton SO17 1BJ, UK;4. Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, University College London, 256 Gray’s Inn Road, London WC1X 8LD, UK;5. WCU Research Centre of Nanobiomedical Science, Dankook University, San#29, Anseo-dong, Dongnam-gu, Cheonan-si, Chungnam 330-714, South Korea;6. Department of Materials Science and Engineering, Institute of Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen, Germany |
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| Abstract: | Novel Poly(3-hydroxybutyrate)/Poly(3-hydroxyoctanoate) blends were developed with varying amounts of Poly(3-hydroxyoctanoate), P(3HO) and Poly(3-hydroxybutyrate), P(3HB) for their potential use in various medical applications. These blend films exhibited higher tensile strength and Young’s modulus values compared to neat P(3HO). The overall protein adsorption and % cell viability was also found to be significantly higher in the blend films than the neat P(3HO) film. Hydrolytic degradation was faster in the blend films and the degradation rate could potentially be tailored to achieve the optimum rate required for a particular medical application. Hence, these novel blends were found to be highly biocompatible with surface, mechanical and thermal properties suitable for a range of potential medical applications, a great step forward in the area of medical materials. |
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| Keywords: | Polyhydroxyalkanoates Cytotoxicity Biodegradability Poly(3-hydroxyoctanoate) Poly(3-hydroxybutyrate) |
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