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Polar Mapper: a computational tool for integrated visualization of protein interaction networks and mRNA expression data |
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| Authors: | Joana P. Gon?alves Mário Gr?os André X.C.N. Valente |
| Affiliation: | 1.Unidade de Sistemas Biológicos, Biocant, 3060-197 Cantanhede, Portugal;2.KDBIO Group, INESC-ID, 1000-029 Lisbon, Portugal;3.IST, Technical University of Lisbon, 1169-047 Lisbon, Portugal;4.Unidade de Biologia Celular, Biocant, 3060-197 Cantanhede, Portugal;5.Centro de Neurociências e Biologia Celular, Universidade de Coimbra, 3004-517 Coimbra, Portugal |
| Abstract: | Polar Mapper is a computational application for exposing the architecture of protein interaction networks. It facilitates the system-level analysis of mRNA expression data in the context of the underlying protein interaction network. Preliminary analysis of a human protein interaction network and comparison of the yeast oxidative stress and heat shock gene expression responses are addressed as case studies. |
| Keywords: | protein interaction network functional genomics systems biology |