Hollow structures as drug carriers:Recognition,response,and release |
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作者姓名: | Decai Zhao Nailiang Yang Lekai Xu Jiang Du Yang Yang Dan Wang |
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作者单位: | State Key Laboratory of Biochemical Engineering;University of Chinese Academy of Sciences;Green Catalysis Center;Department of Thoracic Surgery;School of Materials Science and Engineering |
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基金项目: | supported by the National Natural Science Foundation of China(Nos.21821005,21820102002,and 21971244);the National Key R&D Program of China(No.2016YFB0600903). |
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摘 要: | Hollow structures have demonstrated great potential in drug delivery owing to their privileged structure,such as high surface-to-volume ratio,low density,large cavities,and hierarchical pores.In this review,we provide a comprehensive overview of hollow structured materials applied in targeting recognition,smart response,and drug release,and we have addressed the possible chemical factors and reactions in these three processes.The advantages of hollow nanostructures are summarized as follows:hollow cavity contributes to large loading capacity;a tailored structure helps controllable drug release;variable compounds adapt to flexible application;surface modification facilitates smart responsive release.Especially,because the multiple physical barriers and chemical interactions can be induced by multishells,hollow multishelled structure is considered as a promising material with unique loading and releasing properties.Finally,we conclude this review with some perspectives on the future research and development of the hollow structures as drug carriers.
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关 键 词: | hollow structure drug delivery system carriers SPATIOTEMPORAL |
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