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| 奈韦拉平重要中间体CAPIC制备过程中副产物的研究 | |
| 引用本文： | 宋懿嘉,龙中柱,葛梅,韩中坚.奈韦拉平重要中间体CAPIC制备过程中副产物的研究[J].上海化工,2010,35(9):9-11. |
| 作者姓名： | 宋懿嘉 龙中柱 葛梅 韩中坚 |
| 作者单位： | 1. 上海交通大学,上海,200037 2. 上海东岳生物化工有限公司,上海,200237 3. 上海水基环境工程有限公司,上海,200135 |
| 摘 要： | 利用波谱分析技术鉴定了CAPIC（2-氯-3-氨基-4-甲基吡啶）制备过程中的杂质结构,并由此推测该杂质产生的原因,提出了抑制形成该杂质副反应的方法,为工业化大规模生产奠定了基础。 |
| 关 键 词： | 2-氯-3-氨基-4-甲基吡啶 杂质结构分析 1↑H NMR HPLC |
Study on the By-product Produced During the Scale-up of Drug Intermediate2-chloro-3-amino-4-methylpyridine |
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| Song Yijia,Long Zhongzhu,Ge Mei,Han Zhongjian.Study on the By-product Produced During the Scale-up of Drug Intermediate2-chloro-3-amino-4-methylpyridine[J].Shanghai Chemical Industry,2010,35(9):9-11. | |
| Authors: | Song Yijia Long Zhongzhu Ge Mei Han Zhongjian |
| Affiliation: | Song Yijia Long Zhongzhu Ge Mei Han Zhongjian |
| Abstract: | The structure of the impurity in the preparation of 2-chloro-3-amino-4-methylpyridine was identified by various of spectroscopies.Furthermore,the cause and mechanism of the production of the impurity was discussed and the method for controlling the impurity lovel was suggested,providing the basis for the scale up of 2-chloro-3-amino-4-methylpyridine. |
| Keywords: | 1H NMR HPLC |
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