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| 一种简便的5-氨基-1-羟乙基吡唑合成方法 | |
| 引用本文： | 蔡继平,蒋华江,张建萍. 一种简便的5-氨基-1-羟乙基吡唑合成方法[J]. 浙江化工, 2006, 37(5): 8-9 |
| 作者姓名： | 蔡继平 蒋华江 张建萍 |
| 作者单位： | 1. 浙江工业大学药学院,浙江,杭州,310014;浙江同丰医药化工有限公司,浙江,临海,317024 2. 台州学院生命科学与医药化工学院,浙江,临海,317000 3. 浙江工业大学药学院,浙江,杭州,310014 |
| 摘 要： | 以乙氧亚甲基氰乙酸乙酯和羟乙基肼为原料，经环合、水解等一锅法合成5-氨基吡唑-4-甲酸，然后加热脱羧得到5-氨基-1-羟乙基吡唑。该工艺路线同现有文献相比，不仅总产率较高，而且简化了合成工艺，节省了原料和成本，减少对环境的污染。产品经岛津FTIR-8400型红外分光光度计和NMR-500型核磁共振仪进行结构表征，WATERS-600E型HPLC测定含量。 |
| 关 键 词： | 乙氧亚甲基氰乙酸乙酯 合成 羟乙基肼 5-氨基-1-羟乙基吡唑 |
| 文章编号： | 1006-4184(2006)05-0008-02 |
| 修稿时间： | 2006-03-17 |
A Convenient Procedure for Synthesis of 5-Amino-1-Hydroxyethylpyrazole |
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| CAI Ji-ping,JIANG Hua-jiang,ZHANG Jian-ping. A Convenient Procedure for Synthesis of 5-Amino-1-Hydroxyethylpyrazole[J]. Zhejiang Chemical Industry, 2006, 37(5): 8-9 | |
| Authors: | CAI Ji-ping JIANG Hua-jiang ZHANG Jian-ping |
| Abstract: | 5-Amino-1-hydroxyethylpyrazole was synthesized via cyclic action,hydrolysis and decarboxylation reaction using ethyl ethoxymethylenecyanoacetate and hydroxyethylhydrazine as substrates.It is a convenient and efficient method in high yield and high purities comparison with literature.The product was characterized with FTIR-8400,HPLC WATERS-600 E type and 500MHZ Bruker spectrometer. |
| Keywords: | ethylethoxymethylenecyanoacetate synthesis hydroxyethylhydrazine 5-Amino-1-hydroxyethylpyrazole |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |