Sustained Release Formulation of Salbutamol Sulphate |
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Authors: | R S R Murthy M Malhotra B D Miglani |
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Affiliation: |
a College of Pharmacy, New Delhi |
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Abstract: | Sustained release tablets containing salbutamol sulphate has been prepared by wax matrix granulation method and were evaluated for in vitro release profile and in vivo availability studies in dogs. Out of the release retarding waxy materials used combinations of carnauba wax and stearyl alcohol in concentration range between 60 to 70% of the weight of the tablet were found to be optimum in fabricating sustained release tablets for twentyfour hours duration of action. The formulations were also compared with marketed products of salbutamol for in vitro release profile. |
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