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Application of two-dimensional gel-based mass spectrometry to functionally dissect resistance to targeted cancer therapy
Authors:Oliver Klein  Nadine Rohwer  Katja Freitag de Molina  Stefan Mergler  Petra Wessendorf  Marion Herrmann  Joachim Klose  Thorsten Cramer
Affiliation:1. Berlin-Brandenburg Center for Regenerative Therapies, Charité – Universitätsmedizin Berlin, Berlin, Germany

Core Unit Proteomics, Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany

Institute of Medical and Human Genetics, Charité – Universitätsmedizin Berlin, Berlin, Germany

These authors contributed equally to this work.;2. Department of Hepatology and Gastroenterology, Charité – Universitätsmedizin Berlin, Berlin, Germany

Molekulares Krebsforschungszentrum (MKFZ), Charité – Universitätsmedizin Berlin, Berlin, Germany

These authors contributed equally to this work.;3. German Consortium for Translational Cancer Research (DKTK), Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany;4. Department of Ophthalmology, Charité – Universitätsmedizin Berlin, Berlin, Germany;5. Institute of Medical and Human Genetics, Charité – Universitätsmedizin Berlin, Berlin, Germany;6. Berlin-Brandenburg Center for Regenerative Therapies, Charité – Universitätsmedizin Berlin, Berlin, Germany

Core Unit Proteomics, Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany

Institute of Medical and Human Genetics, Charité – Universitätsmedizin Berlin, Berlin, Germany

These authors jointly directed this work.

Correspondence: Professor Joachim Klose, Berlin-Brandenburg Center for Regenerative Therapies, Core Unit Proteomics and Institute of Medical and Human Genetics, Charité – Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany

E-mail:joachim.klose@charite.de

Fax: +49-30-450-566-904;7. Department of Hepatology and Gastroenterology, Charité – Universitätsmedizin Berlin, Berlin, Germany

Molekulares Krebsforschungszentrum (MKFZ), Charité – Universitätsmedizin Berlin, Berlin, Germany

These authors jointly directed this work.

Abstract:
Keywords:2DE  Gastric cancer  HIF-1α  Targeted therapy  Therapy resistance
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