Synthesis and characterization of poly(ε-caprolactone)-containing amino acid-based poly(ether ester amide)s |
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Authors: | Kai Guo C C Chu |
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Affiliation: | Department of Fiber Science and Apparel Design and Biomedical Engineering Program, Cornell University, Ithaca, New York 14853-4401 |
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Abstract: | A new family of biodegradable amino acid-based poly(ether ester amide)s (AA-PEEAs) consisting of three building blocks poly(ε-caprolactone) (PCL), L -phenylalanine (Phe), and aliphatic acid dichloride] were synthesized by a solution polycondensation. Using DMA as the solvent, these PCL-containing Phe-PEEA polymers were obtained with fair to very good yields with weight average molecular weight (Mw) ranging from 6.9 kg/mol to 31.0 kg/mol, depending on the original molecular weight of PCL. The chemical structures of the PCL-containing Phe-PEEA polymers were confirmed by IR and NMR spectra. These PCL-containing Phe-PEEAs had lower Tg than most of the oligoethylene glycol (OEG) based AA-PEEAs due to the more molecular flexibility of the PCL block in the backbones, but had higher Tg than non-amino acid based PEEA. The solubility of the PCL-containing Phe-PEEA polymers in a wide range of common organic solvents, such as THF and chloroform, was significantly improved when comparing with aliphatic diol based poly(ester amide)s and OEG based AA-PEEAs. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012 |
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Keywords: | amino acids poly(ether ester amide) polycaprolactone biodegradable polymers unsaturated biodegradable polymers polycondensation |
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