Prognostic significance of p53 gene mutations in squamous cell carcinoma of the lung |
| |
Authors: | A Sánchez-Pernaute A Torres P Iniesta F Hernando A Gómez O González C De Juan E Pérez-Aguirre ML Maestro JA López-Asenjo M Benito JL Balibrea |
| |
Affiliation: | Servicio de Cirugia II, 3a planta, ala Sur, Hospital Universitario San Carlos, C/Martin Lagos s/n, Madrid 28040, Spain. |
| |
Abstract: | The aim of the present study was to analyze the prevalence and clinical importance of p53 gene mutations in surgically treated squamous cell lung carcinoma. Sixty patients were included. Fifty-one patients in stages I to IIIa were submitted to radical resection. Twenty-five samples tested positive for the p53 immunohistochemistry assay, and were analyzed for p53 gene mutations. Eleven mutations were found. Patients harboring p53 gene mutations suffered a higher incidence of recurrence and a higher mortality rate. Disease-free interval and overall survival were shorter for patients with mutated p53 gene (p=0.03 and p=0.005, respectively). |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|