智能响应型纳米药物载体的研究进展

近年来智能响应型纳米药物载体在抗肿瘤药物的递送中得到了广泛关注。该文根据智能响应型纳米药物载体是否具有主动靶向性,将其分为非靶向智能响应型纳米药物载体和靶向智能响应型纳米药物载体,并分别对这两者纳米药物载体的新研究和新进展进行了综述。同时,总结了智能响应型纳米药物载体当前存在的问题。与非靶向智能响应型纳米药物载体相比,靶向智能响应型纳米药物载体具有更多的优势,尤其是靶向肿瘤组织中特异性过表达酶的智能响应型纳米药物载体将会是今后纳米药物载体研究的一个重要方向。

A Progress in Smart Nanocarrier System for Drug Delivery

Malignant tumor is one of the disease with the highest mortality rate worldwide. In clinic, the common treatment methods include chemotherapy, radiotherapy and surgery, and majority of patient after surgical treatment also need adjuvant chemotherapy. In order to achieve targeted delivery and quickly release of the drug at the tumor site, stimuli-responsive smart nanocarrier system has received extensive attention. The smart nanocarrier system mainly include tumor?microenvironment stimuli-responsive?smart?nanocarrier system and external physical stimuli-responsive?smart?nanocarrier system. Smart nanocarrier system can transport antitumor drug in circulation stably. After arriving the tumor site, the drug can quickly release from the smart nanocarrier system after triggered by the tumor microenvironment or external physical stimuli, which could improve the drug concentration of the lesion,significantly?increase?the?antitumor?efficiency?and?reduce?the?side?effects?of?drugs.This?review?mainly?gives?a?comprehensive?overview?in?the?latest?research?and?new?development?of smart nanocarrier system, targeted smart nanocarrier system and multifunctional smart nanocarrier system. Moreover, the existingproblems are pointed out along with their possible future applications in this review.