| 生物医用磁性纳米颗粒的制备与表面改性 |
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| 引用本文： | 徐晓雪,李莉,郑玉峰. 生物医用磁性纳米颗粒的制备与表面改性[J]. 材料科学与工艺, 2008, 16(4): 562-568 |
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| 作者姓名： | 徐晓雪 李莉 郑玉峰 |
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| 作者单位： | 哈尔滨工程大学生物医学材料与工程研究中心,哈尔滨,150001;哈尔滨工程大学生物医学材料与工程研究中心,哈尔滨,150001;哈尔滨工程大学生物医学材料与工程研究中心,哈尔滨,150001 |
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| 基金项目： | 黑龙江省哈尔滨市青年科学基金 |
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| 摘 要： | 磁性纳米颗粒目前是生物医用纳米材料领域异常活跃的方向之一.不同方法制备的磁性纳米颗粒经不同聚合物或分子表面改性后具有多方面的生物医学应用.本文综合评述了磁性纳米颗粒的制备方法,如共沉淀法、溶胶-凝胶法、微乳剂法等;总结了磁性纳米颗粒表面改性技术,包括改性物质与改性方法;概括了磁性纳米颗粒在生物医学领域的应用,主要涉及磁靶向制剂、细胞分离、肿瘤细胞的过热治疗、MR I衬度增强剂四方面.磁性纳米颗粒还有很大的发展空间和广阔的应用前景.
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| 关 键 词： | 磁性纳米颗粒 制备 表面改性 生物医学应用 |
Preparation and surface modification of magnetic nanoparticles for biomedical applications |
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| XU Xiao-xue,LI Li,ZHENG Yu-feng. Preparation and surface modification of magnetic nanoparticles for biomedical applications[J]. Materials Science and Technology, 2008, 16(4): 562-568 |
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| Authors: | XU Xiao-xue LI Li ZHENG Yu-feng |
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| Affiliation: | (Center of Biomedical Material and Engineering,Harbin Engineering University,Harbin 150001,China) |
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| Abstract: | Magnetic nanoparticle is one of the hot research directions in the field of nano-biomedical materials.The magnetic nanoparticles prepared by different methods and modified with different polymers are used in various fields.In this paper,we synthetically summarize its preparation methods including co-precipitation,sol-gel,microemulsion,generalize the surface modification technique with different polymers,and report the biomedical applications of magnetic nanoparticles involving target drug delivery,cell separation hyperthermic treatment for malignant cells and MRI contrast enhancement.Magnetic nanoparticles still have great potentials for development and application in the future. |
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| Keywords: | magnetic nanoparticles preparation surface modification biomedical applications |
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