Anterior segment characteristics of keratoconus eyes in a sample of Asian population |
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| Affiliation: | 1. School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Malaysia;2. Sungai Buloh Hospital, Selangor, Malaysia;2. Faculty of Medicine, University of Toronto, Toronto, Ont.;3. Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ont.;4. Centre for Vision Research, York University, Toronto, Ont.;1. Medical Informatics and Statistics Group, University of Oulu, PO Box 5000, 90014 Oulu, Finland;2. Centre for Arctic Medicine, Thule Institute, University of Oulu, Finland;3. Research Unit of Biomedicine, University of Oulu, Finland;4. School of Pharmacy/Toxicology, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland;1. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California;2. Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California;1. Aravind Eye Hospital, Pondicherry, India;2. Dana Center for Preventive Ophthalmology, Johns Hopkins University, Baltimore, Maryland;3. Wilmer Eye Institute, John Hopkins University, Baltimore, Maryland;4. Aravind Eye Hospital, Tirunelveli, India;5. Aravind Eye Hospital, Coimbatore, India;6. Aravind Eye Hospital, Madurai, India |
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| Abstract: | PurposeTo assess changes in anterior segment parameters of keratoconus eyes at different stages of the disease in a sample of the Asian population.MethodsFiles of 32 patients (48 eyes) diagnosed as clinical keratoconus were assessed and the following parameters noted: central corneal thickness (CCT), thinnest corneal thickness (TCT), location of thinnest pachymetry, anterior chamber depth (ACD) at the centre from posterior corneal surface, ACD at 1, 2 and 3 mm inferior-paracentral, ACD at thinnest pachymetry, anterior chamber volume (ACV) and anterior chamber angle (ACA). For analysis, keratoconus eyes were classified into 3 subgroups according to mean keratometry readings (mild: K ≤ 47.0 D, moderate: 47.0 < K < 52.0 D, and severe: K ≥ 52.0 D). Forty-five subjects (45 right eyes) were recruited as a control group. They underwent Pentacam tomographic evaluation. The same parameters were recorded for control subjects as in the keratoconus patients.ResultsEach keratoconus subgroup comprised of 16 eyes. CCT, TCT, ACD at centre, ACD at 1, 2 mm inferior-paracentral and ACD at thinnest pachymetry were statistically different between mild and severe keratoconus groups (P < 0.05). There were also significant differences between normal with each of the moderate and severe keratoconus groups (P < 0.05). Non-significant differences were found in ACV (P = 0.84) and ACA (P = 0.71) between all measured groups.ConclusionWith the exception of ACV and ACA, parameters that include CCT, TCT, ACD at centre, thinnest pachymetry and 1, 2 mm inferior-paracentral were significantly altered with progression of keratoconus. These findings may be useful in monitoring and management of keratoconus patients. |
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