| Effects of Antihepatocarcinoma with Apatite Nanoparticles in vivo |
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| 作者姓名： | YIN Meizhen HAN Yingchao DAI Honglian LI Shipu |
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| 作者单位： | Biomedical Materials and Engineering Center ~ Wuhan University of Technology, Wuhan 430070, China |
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| 基金项目： | 湖北省科技创新项目，国家自然科学基金 |
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| 摘 要： | The inhibition effect of hydroxyapatite （ HAP ） nanoparticles on hepatocarcinoma was investigated in vivo. The human hepatocarcinoma cell line Bel- 7402 was transplanted subcutaneously into nude mice. Hydroxyapatite nanoparticles suspension at a dose of 0. 2 mL was injected into the transplanted tumors every day for 2 weeks, and saline was used us control. The efficacy of hydroxyapatite nanoparticles on this carcinoma was surveyed and morphological changes of tissue and cells were observed by light microscopy and transmission electron microscopy （TEM）. Experimental results show that hydroxyapatite nanoparticles have a visible destructive effect on the structures of hepatocarcinoma cells and tissue. The inhibition rates of tumor growth were 77.21% and 51. 32% after intra-tumor injection of hydroxyapatite nanoparticles for 1 week and 2 weeks, respectively. Compared with the control group, hydroxyapatite nanoparticles can also prolong the survival time of the nude mice bearing this cancer significantly. This indicates that hydroxyapatite nanoparticles have the therapeutic potential on hepatoma in vivo.
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| 关 键 词： | 磷灰石毫微粒 HAP 羟磷灰石毫微粒 悬浮 |
| 收稿时间： | 2005-08-05 |
| 修稿时间： | 2006-07-13 |
Effects of antihepatocarcinoma with apatite nanoparticles in vivo |
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| YIN Meizhen HAN Yingchao DAI Honglian LI Shipu.Effects of Antihepatocarcinoma with Apatite Nanoparticles in vivo[J].Journal of Wuhan University of Technology. Materials Science Edition,2006,21(4):102-104. |
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| Authors: | Yin Meizhen Ph D Candidate Han Yingchao Dai Honglian Li Shipu |
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| Affiliation: | (1) Biomedical Materials and Engineering Center, Wuhan University of Technology, 430070 Wuhan, China |
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| Abstract: | The inhibition effect of hydroxyapatite (HAP) nanoparticles on hepatocarcinoma was investigated in vivo. The human hepatocarcinoma cell line Bel-7402 was transplanted subcutaneously into nude mice. Hydroxyapatite nanoparticles suspension at a dose of 0.2 mL was injected into the transplanted tumors every day for 2 weeks, and saline was used as control. The efficacy of hydroxyapatite nanoparticles on this carcinoma was surveyed and morphological changes of tissue and cells were observed by light microscopy and transmission electron microscopy (TEM). Experimental results show that hydroxyapatite nanoparticles have a visible destructive effect on the structures of hepatocarcinoma cells and tissue. The inhibition rates of tumor growth were 77.21% and 51. 32% after intra- tumor injection of hydroxyapatite nanoparticles for 1 week and 2 weeks, respectively. Compared with the control group, hydroxyapatite nanoparticles can also prolong the survival time of the nude mice bearing this cancer significantly. This indicates that hydroxyapatite nanoparticles have the therapeutic potential on hepatoma in vivo. |
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| Keywords: | hydroxyapatite nanoparticles hepatocarcinoma transplantation nude mice |
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