Contribution à l'étude expérimentale de la séborrhée. Implications éventuelles en cosmétologie

The sebaceous gland is an androgen-dependent structure and a major site for androgen metabolism. Androgens are involved in stimulation of sebaceous secretion in humans. The object of this study is to contribute to the understanding of the role of these hormones and their metabolites in seborrhea and to comment on the activity of certain inhibitors. Methods used are sebaceous secretion and ¹⁴C-lipogenesis in animals, ¹⁴C-testosterone or DHA metabolism in animal and human skin. Our results showed that: – by subcutaneous administration in rats, there was a relative specificity of weak androgens for sebaceous gland stimulation unlike potent androgens.