| 载紫杉醇聚乳酸-羟基乙酸纳米粒的体外释药研究 |
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| 引用本文： | 裘迪,朱宏. 载紫杉醇聚乳酸-羟基乙酸纳米粒的体外释药研究[J]. 材料导报, 2009, 23(Z2) |
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| 作者姓名： | 裘迪 朱宏 |
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| 作者单位： | 南京工业大学材料科学与工程学院,南京,210009 |
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| 摘 要： | 以生物可降解材料聚乳酸-羟基乙酸(PLGA)为载体制备了载紫杉醇纳米粒,重点考察了纳米粒的体外释放特性.采用乳化-溶剂挥发法制备了载紫杉醇PLGA纳米粒,其平均粒径为200nm,载药量为21%,包封率为89.44%;体外释药符合Higuchi方程:Q=3.8796t1/2+30.4649(r=0.9397),同时载紫杉醇纳米粒具有一定的缓释作用.
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| 关 键 词： | 聚乳酸-羟基乙酸 纳米粒 紫杉醇 体外释放 |
Release Study of Paclitaxel Loaded PLGA Nanoparticles in vitro |
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| QIU Di,ZHU Hong. Release Study of Paclitaxel Loaded PLGA Nanoparticles in vitro[J]. Materials Review, 2009, 23(Z2) |
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| Authors: | QIU Di ZHU Hong |
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| Abstract: | Paclitaxel loaded nanoparticles are prepared using biodegradable materials poly(lactic-co-glycolic acid)(PLGA) as drug carrier, with an emphasis on the release behavior study of the nanoparticles in vitro. Paclitaxel loaded PLGA nanoparticles are made by emulsion(O/W)-solvent evaporation process. The mean size, drug loading, encapsulation efficiency of paclitaxel loaded PLGA nanoparticles are 200nm, 21 %, 89. 44% respectively. The in vitro release properties can be expressed by the Higuchi's equation Q=3. 8796t1/2 +30. 4649(r=0. 9397) ,and paclitaxel loaded PLGA nanoparticles show sustained release. |
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| Keywords: | PLGA nanoparticles paclitaxel in vitro release |
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