Lipid-lowering action of pectin from Cucumis sativus |
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| Affiliation: | 1. NIVEL, Netherlands Institute for Health Services Research, P.O. Box 1568, 3500 BN Utrecht, Netherlands;2. Leids Universitair Medisch Centrum, Department of Medical Decision Making, P.O. Box 9600, 2300 RC Leiden, Netherlands;3. University of York, Centre for Health Economics, University of York, Heslington, York YO10 5DD, UK;1. Ministry of Education Key Lab of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China;2. Zhejiang Provincial Key Laboratory of Subtropic Soil and Plant Nutrition, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China;3. State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou 310006, China;4. National Engineering Laboratory for Efficient Utilization of Soil and Fertilizer Resources, Shandong Agricultural University, Taian, Shandong 271018, China;1. Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran;2. Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran;3. Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran;4. Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran |
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| Abstract: | The oral administration of the pectin extracted from the fruit of Cucumis sativus at a dose of 5 g kg−1 body weight day−1 showed significant hypolipidemic action in normal as well as cholesterol-fed experimental animals. Concentrations of cholesterol, triglycerides, phospholipids and free fatty acids were found to be significantly reduced in the serum and tissues of experimental animals. Activity of HMG CoA reductase was found to be enhanced. Pectin administration decreased the activities of glucose-6-phosphate dehydrogenase and malate dehydrogenase while it increased the activities of lipoprotein lipase and plasma LCAT. Incorporation of labelled 14C acetate into free cholesterol was significantly higher in the liver of pectin-treated rats. Concentrations of bile acids (hepatic and fecal) and fecal neutral sterols showed significant increases in the pectin-administered groups. |
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