水合肼还原芳硝基物的研究

以Pd C为催化剂 ,水合肼为还原剂研究了p 硝基乙酰苯胺、p 硝基氯苯以及 3 硝基 4 甲氧基乙酰苯胺的还原反应 ,反应在液相色谱跟踪下进行。80℃下p 硝基乙酰苯胺及p 硝基氯苯还原转化率达 10 0 %所需的条件分别为 :n(p NO2 C6 H4NHCOCH3)∶n(N2 H4H2 O) =1 0∶1 6、催化剂用量 11 33g (molp 硝基乙酰苯胺 )、反应时间 3h ;n(p NO2 C6 H4Cl)∶n(N2 H4H2 O) =1 0∶1 8、催化剂用量 10g (molp 硝基氯苯 )、反应时间 2 0min ;还原最终产物组成单一 ,均为相应的氨基物

Reduction of Aromatic Nitro Compounds with Hydrazine Hydrate

p-Nitroacetanilied,p-nitrochlorobenzene and 3-nitro-4-methoxyacetanilied were reduced by hydrazine hydrate in the presence of Pd/C catalyst. The reduction of three aromatic nitro compounds was tracked by monitoring with HPLC. The conversion of p- nitroacetanilide and p-nitrochlorbenzene was 100％ when n(p-NO2C6H4NHCOCH3): n(N2H4H2O) = 1.0: 1.6,Pt/C = 11.33 g/mol p-nitroacetanilide,reaction time = 3 h and reaction temperature = 80 ℃, and n(NO2 NO2C6H4Cl):n(N2H4H2O) = 1.0:1.8,Pt/C = 10 g/mol p- nitrochlorbenzene, reaction time = 20 rmin and reaction temperature = 80 ℃.The final products were the corresponding amino compounds.