Vital role of hydroxyapatite particle shape in regulating the porosity and mechanical properties of the sintered scaffolds |
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| Authors: | Jinchuan Wu Changshun Ruan Yufei Ma Yuanliang Wang Yanfeng Luo |
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| Affiliation: | 1. Lab for Bioinspired & Smart Materials, College of Bioengineering, Chongqing University, Chongqing 400030, China;2. Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Chongqing 400030, China;3. Center for Human Tissue and Organs Degeneration, Institute of biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Science, Shenzhen 518055, China |
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| Abstract: | The effect of particle shape on the porosity and compressive strength of porous hydroxyapatite (HA) scaffolds was investigated by sintering the mixture of rod-shaped HA (r-HA) and spherical HA (s-HA) with polyacrylamide used as the sacrificial template. It was found, for the first time, that addition of r-HA into s-HA could exponentially decrease the porosity of sintered HA scaffolds and enhance their compressive strength with the increase of r-HA content. The mechanism, according to the results from scanning electron microscopy and X-ray diffraction, lies in the restriction of s-HA to the grain formation and growth of r-HA during sintering and results in the fusion of r-HA with s-HA. These findings suggest that mixture of r-HA and s-HA might provide a new and facile way to improve the compressive strength of porous HA scaffolds. |
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| Keywords: | Spherical/rod-shaped hydroxyapatite Bioceramics Porous materials Sintering Compressive strength |
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