麻疹疫苗免疫持久性研究——再免后22年追踪观察

目的 研究麻疹疫苗初免后不同间隔时间再免疫的血清抗体持久性。方法 采用血凝抑制试验方法检测329名观察对象血清中的麻疹抗体滴度。结果 麻疹疫苗初免后,不同间隔时间再免疫,相同抗体水平者再免与不再免疫,血清抗体阴转率差异均无显著意义。再免是否成功与再免前的血清抗体水平密切相关,而且,再免成功与否对免疫持久性无显著影响。再免疫可使抗体阴转和低抗体水平者的滴度迅速提高。结论 初免麻疹疫苗获得成功后,再免疫仅能暂时提高群体血清抗体滴度,但对延长抗体持久性无明显作用。

Antibody Persistence of Measles Vaccine:A 22-Years Follow-up after Booster Immunization

Objective To explore the persistence of serum antibody induced by booster immunizaiton with measles vaccine at different time after primary immunization. Methods The measles antidody titers in the sera of 329 subjects were detected by HI test. Results No significant differences were observed in the serum antibody negative conversion rates induced with the boosters given at different time after primary immunization . The negative conversion rates induced with or without boosters also showed no singnificant differences in the subjects with the same antibody levels after primary immunization .However,though the success of booster immunization was closely related to the previous serum antibody level, it showed no significant influence on the persistence of antibody. The antibody titers of subjects without or with low antibody levels increased significantly after booster immunization. Conclusion Booster immunization can increase the serum antibody titers of subject temporarily. However,it shows no significant effect on antidody persistence.