The aged suprachiasmatic nucleus is phase-shifted by cAMP in vitro |
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| Authors: | NF Ruby DM Edgar HC Heller JD Miller |
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| Affiliation: | Department of Biological Sciences, Stanford University, CA 94305, USA. ruby@leland.stanford.edu |
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| Abstract: | The cyclic adenosine monophosphate (cAMP) analog, 8-bromo-cAMP, phase advanced circadian neuronal rhythms in both aged and adult rat suprachiasmatic nuclei (SCN) by approximately 2 h in vitro. Rhythm amplitude was 20% lower in aged compared to adult SCN. The diminished efficacy of serotonergic agonists to phase shift behavioral rhythms of aged animals may be due to decrements in signal transduction mechanisms proximal to cAMP. |
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