| 双歧杆菌和嗜酸乳杆菌二联活菌微胶囊的研制 |
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| 引用本文： | 张玉华,凌沛学,籍保平,张天民.双歧杆菌和嗜酸乳杆菌二联活菌微胶囊的研制[J].食品与药品,2009(7). |
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| 作者姓名： | 张玉华 凌沛学 籍保平 张天民 |
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| 作者单位： | 国家农产品现代物流工程技术研究中心;山东商业职业技术学院;山东省药学科学院;中国农业大学食品科学与营养工程学院; |
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| 摘 要： | 目的制备长双歧杆菌和嗜酸乳杆菌二联活菌微胶囊,以期提高口服时的存活率和常温下的保存期。方法根据微胶囊在人工胃液中的耐酸性和在人工肠液中的崩解性,确定空气悬浮法制备微胶囊的最佳工艺条件。扫描电镜观察微胶囊形态与大小。根据恒温37℃、相对湿度60%~65%条件下贮存3个月后菌体存活率,考察其贮存稳定性。结果制备的微胶囊具有良好的耐酸性和肠溶性。微胶囊包囊产率56.49%,包囊效率87.45%。微胶囊表面覆盖着一层光滑平整的囊膜,粒径大小基本在400~500μm。加保护剂的微胶囊菌体存活率高于10%,且远远高于冻干菌粉和无保护剂微胶囊组。结论确定了空气悬浮法制备长双歧杆菌和嗜酸乳杆菌二联活菌微胶囊的最佳工艺条件,微胶囊化有利于提高活菌的稳定性。
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| 关 键 词： | 双歧杆菌 嗜酸乳杆菌 微胶囊 |
Development of Microcapsule Containing Bifidobacterium and Lactobacillus acidophilus |
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| ZHANG Yu-hua,LING Pei-xue,JI Bao-ping,ZHANG Tian-min.Development of Microcapsule Containing Bifidobacterium and Lactobacillus acidophilus[J].Food and Drug,2009(7). |
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| Authors: | ZHANG Yu-hua LING Pei-xue JI Bao-ping ZHANG Tian-min |
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| Affiliation: | 1.National Engineering Research Center for Agricultural Products Logistics;Shandong Institute of Commerce and Technology;Jinan 250103;China;2.Shandong Academy of Pharmaceutical Science;Jinan 250101;3.College of Food Science & Nutritional Engineering;China Agricultural University;Beijing 100083;China |
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| Abstract: | Objective To prepare the microcapsule containing Bifidobacterium and Lactobacillus acidophilus in order to improve the oral survival rate and shelf life at room temperature.Methods According to the acid-resistance in artificial gastric juice and collapse in artificial intestinal juice of microcapsule,the optimal technological conditions were ascertained for the preparation of microcapsule with air suspension.The shape and size of microcapsule were observed with scanning electron microscope.The storage stabi... |
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| Keywords: | Bifidobacterium Lactobacillus acidophilus microcapsule |
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