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Continuation Along Bifurcation Branches for a Tumor Model with a Necrotic Core
Authors:Wenrui Hao  Jonathan D Hauenstein  Bei Hu  Yuan Liu  Andrew J Sommese  Yong-Tao Zhang
Affiliation:1. Department of Applied and Computational Mathematics and Statistics, University of Notre Dame, Notre Dame, IN, 46556, USA
2. Department of Mathematics, Texas A&M University, College Station, TX, 77843-3368, USA
Abstract:We consider a free boundary problem for a system of partial differential equations, which arises in a model of tumor growth with a necrotic core. For any positive number R and 0<??<R, there exists a radially-symmetric stationary solution with tumor free boundary r=R and necrotic free boundary r=??. The system depends on a positive parameter ??, which describes tumor aggressiveness, and for a sequence of values ?? 2<?? 3<??, there exist branches of symmetry-breaking stationary solutions, which bifurcate from these values. Upon discretizing this model, we obtain a family of polynomial systems parameterized by tumor aggressiveness factor???. By continuously changing ?? using a homotopy, we are able to compute nonradial symmetric solutions. We additionally discuss linear and nonlinear stability of such solutions.
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