Synthesis of DHPA analogs and their inhibitory activities of human recombinant S-adenosyl-L-homocysteine hydrolase |
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| Authors: | Y Kitade M Nakanishi A Hosoya A Hiraoka M Hayashi K Mori T Gotoh C Yatome |
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| Affiliation: | Department of Biomolecular Science, Faculty of Engineering, Gifu University, Japan. |
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| Abstract: | We report syntheses of DHPA analogs, e.g., 9-(3-formyl-2,3-dihydroxypropyl)adenine (FDHPA) and 9-(3-formyl-2,3-dihydroxypropyl)hypoxanthine (FDHPI). Among these DHPA analogs, FDHPA behaved as an irreversible inactivator of human recombinant SAH hydrolase. |
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