Periodic mesoporous silica and organosilica with controlled morphologies as carriers for drug release |
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| Authors: | Chun Xiang Lin Shi Zhang Qiao Cheng Zhong Yu Suryadi Ismadji Gao Qing Lu |
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| Affiliation: | 1. ARC Centre of Excellence for Functional Nanomaterials, School of Engineering and Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St. Lucia, QLD 4072, Australia;2. Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, PR China;3. Department of Chemical Engineering, Widya Mandala Surabaya Catholic University, Surabaya 60114, Indonesia;1. Key Laboratory of Magnetic Materials and Devices & Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, PR China;2. Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, PR China;3. State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China;1. International Center for Materials Nanoarchitechtonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan;2. Organic and Nano Group (ONG), Department of Chemistry, Faculty of Science, University of Maragheh, Maragheh 55181-83111, Iran;3. Young Researchers and Elite Club, West Tehran Branch, Islamic Azad University, Tehran, Iran;4. Graduate School of Engineering, Department of Applied Chemistry, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima 739-8527, Japan;5. School of Materials Science and Engineering, UNSW Sydney, 2052, Australia;1. Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014, Helsinki, Finland;2. Department of Micro and Nanotechnology, Technical University of Denmark, 2800, KGs.Lyngby, Denmark;3. Laboratory of Tissue Engineering, Institute of Theoretical and Experimental Biophysics, Russian Academy of Science, Institutskaya 3, Pushchino, 142290, Moscow Region, Russia;4. Laboratory of Industrial Physics, Department of Physics and Astronomy, University of Turku, FI-20014, Turku, Finland;5. Department of Chemistry, University of Helsinki, FI-00014, Helsinki, Finland;6. Helsinki Institute of Life Sciences (HiLIFE), University of Helsinki, FI-00014, Helsinki, Finland;1. Departamento de Tecnología Química y Energética, Tecnología Química y Ambiental, Tecnología Mecánica y Química Analítica, Universidad Rey Juan Carlos, Móstoles, Spain;2. Department of Chemistry, Faculty of Arts and Sciences, Sakarya University, 54187 Sakarya, Turkey |
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| Abstract: | In this paper, we report the effects of morphology, wall composition of mesoporous materials and different buffer solutions on drug delivery profiles. Hollow spheres of periodic mesoporous organosilica (PMO) were prepared and used as drug carriers which exhibited higher loading capacity and slower release rate compared to the conventional periodic mesoporous silica (PMS) spheres and solid spheres of PMO. This hollow PMO showed promising properties as a reservoir to encapsulate and store larger quantities of guest molecules within its “empty” core. Moreover, its organic reactive sites allowed stronger interactions to the hydrophobic guest molecules, in contrast to inorganic wall possessed by PMS materials. Antibiotic tetracycline was used as a model drug to study the effect of framework difference between PMO and PMS materials on the loading and release processes. Two kinds of release medium, simulated body fluid (SBF) solution (pH 7.4) and phosphate buffer (PB) solution (pH 1.5) were used in this study, which revealed very different release profiles. A slower delivery rate was observed in SBF solution, attributed to the different ionic interactions between the guest molecule and the host material in the two different pH solutions. Overall, hollow PMO shows the lowest release rate and the highest loading amount compared to the other two materials studied herein. The kinetic study reveals that drug release from host material follows the second order kinetic model better than the first order mass transfer model. |
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