DNA origami nanopores |
| |
Authors: | Bell Nicholas A W Engst Christian R Ablay Marc Divitini Giorgio Ducati Caterina Liedl Tim Keyser Ulrich F |
| |
Affiliation: | Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge, CB3 0HE, United Kingdom. |
| |
Abstract: | We demonstrate the assembly of functional hybrid nanopores for single molecule sensing by inserting DNA origami structures into solid-state nanopores. In our experiments, single artificial nanopores based on DNA origami are repeatedly inserted in and ejected from solid-state nanopores with diameters around 15 nm. We show that these hybrid nanopores can be employed for the detection of λ-DNA molecules. Our approach paves the way for future development of adaptable single-molecule nanopore sensors based on the combination of solid-state nanopores and DNA self-assembly. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|