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Apoferritin Modified Magnetic Particles as Doxorubicin Carriers for Anticancer Drug Delivery
Authors:Iva Blazkova  Hoai Viet Nguyen  Simona Dostalova  Pavel Kopel  Maja Stanisavljevic  Marketa Vaculovicova  Marie Stiborova  Tomas Eckschlager  Rene Kizek  Vojtech Adam
Abstract:Magnetic particle mediated transport in combination with nanomaterial based drug carrier has a great potential for targeted cancer therapy. In this study, doxorubicin encapsulation into the apoferritin and its conjugation with magnetic particles was investigated by capillary electrophoresis with laser-induced fluorescence detection (CE-LIF). The quantification of encapsulated doxorubicin was performed by fluorescence spectroscopy and compared to CE-LIF. Moreover, the significant enhancement of the doxorubicin signal was observed by addition of methanol into the sample solution.
Keywords:cancer   nanomedicine   magnetic particles   doxorubicin   nanoparticles
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