The Functions and Applications of RGD in Tumor Therapy and Tissue Engineering |
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| Authors: | Fen Wang Yuanyuan Li Yingqiang Shen Anming Wang Shuling Wang Tian Xie |
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| Affiliation: | 1.College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China; E-Mails: (F.W.); (Y.L.);2.Research Center for Biomedicine and Health, Hangzhou Normal University, Hangzhou 311121, China; E-Mails: (Y.S.); (S.W.);3.College of Biological and Environmental Sciences, Hangzhou Normal University, Hangzhou 310036, China |
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| Abstract: | Arginine-Glycine-Aspartic (RGD), is the specific recognition site of integrins with theirs ligands, and regulates cell-cell and cell-extracellular matrix interactions. The RGD motif can be combined with integrins overexpressed on the tumor neovasculature and tumor cells with a certain affinity, becoming the new target for imaging agents, and drugs, and gene delivery for tumor treatment. Further, RGD as a biomimetic peptide can also promote cell adherence to the matrix, prevent cell apoptosis and accelerate new tissue regeneration. Functionalizing material surfaces with RGD can improve cell/biomaterial interactions, which facilitates the generation of tissue-engineered constructs. This paper reviews the main functions and advantages of RGD, describes the applications of RGD in imaging agents, drugs, gene delivery for tumor therapy, and highlights the role of RGD in promoting the development of tissue engineering (bone regeneration, cornea repair, artificial neovascularization) in recent years. |
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| Keywords: | RGD tumor therapy tissue engineering |
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