The effect of age on peripheral motor nerve function after crush injury in the rat |
| |
Authors: | BM Belin DJ Ball JC Langer PM Bridge PK Hagberg SE Mackinnon |
| |
Affiliation: | Division of Pediatric Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA. |
| |
Abstract: | OBJECTIVE: To determine the ontogeny of functional recovery after peripheral nerve crush injury. DESIGN: Comparative study in rats of varying ages. MATERIAL AND METHODS: Sixty-second crush injury was performed on the left posterior tibial nerve. Control animals underwent either nerve transection or sham procedure. Nerve function was evaluated 2, 4, and 8 weeks following injury by walking track analysis. Print length ratio (PLR), (ratio of normal right-sided print length to experimental left-sided print length), was used to evaluate functional recovery. MEASUREMENTS AND MAIN RESULTS: Two weeks after crush injury, adult rats experienced significantly greater functional impairment than both 4-day-old and 3-week-old animals (p < 0.05). Four weeks after injury, the difference in function between 4-day-old and adult rats and between 3-week-old and adult rats became insignificant. Complete recovery had been achieved by 8 weeks in all groups. CONCLUSIONS: These results demonstrate faster functional recovery after nerve injury in immature rats than in adults. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|