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| Eu（Ⅲ） Indirect Probe to Investigate Interaction of DOPA （3, 4, Di-Hydroxyphenylalanine） and Dopamine （3, 4-Dihydroxy Phenyl Ethyl Amine） Using Electrochemical Methods | |
| 作者姓名： | Prashant N Bhatt Trupti V Pathak Jignasu P Mehta G. Ramchandraiha |
| 作者单位： | [1]Department of Chemistry, Bhavnagar University, Bhavnagar-364002 , India [2]Central Salt and Marine Chemical Research Institute, Waghavadi Road, Bhavnagar-364002 , India |
| 基金项目： | Project supported by DST（SP/S1/F03/98）.Acknowledgment： 0ne of the authors （Trupti V Pathak ） is thankful to CSIR [ 9/802/（ 1 ）/2000 EMR-I ] for the awarded SRF. |
| 摘 要： | Eu（ Ⅲ ） can be utilized as an indirect electrochemical probe to investigate the interaction of bio-molecules such as DOPA and Dopamine with Ca（ Ⅱ ） in vitro. The interaction of DOPA and Dopamine with Eu（ Ⅲ ）-Eu（ Ⅱ ） redox pair was investigated by electrochemical techniques. Both the neurotransmitters are structurally related and undergo interaction with Eu （Ⅲ ）. Eu （ Ⅲ ） coordinates with DOPA and Dopamine through five-member chelate tings via carboxylic oxygen and amino nitrogen. The electrode kinetic parameters viz, transfer coefficient （αna）, diffusion coefficient （D）, forward heterogeneous rate constant （ k^0 fh） were evaluated for Eu（ Ⅲ ）-DOPA/Eu（ Ⅲ ）-Dopamine. The results obtained were used to investigate the nature of interaction of Eu （Ⅲ） with muhi-donor biomolecules. The possible mechanism was also proposed. |
| 关 键 词： | 稀土 铕（Ⅲ）直接探针 电化学 神经递质 DOPA 多巴胺 |
| 文章编号： | 1002-0721（2006）06-0653-06 |
| 收稿时间： | 2006-06-19 |
| 修稿时间： | 2006-10-13 |
Eu (III) Indirect Probe to Investigate Interaction of DOPA (3, 4, Di-Hydroxyphenylalanine) and Dopamine (3, 4-Dihydroxy Phenyl Ethyl Amine) Using Electrochemical Methods |
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| Prashant N Bhatt Trupti V Pathak Jignasu P Mehta G. Ramchandraiha.Eu (III) Indirect Probe to Investigate Interaction of DOPA (3, 4, Di-Hydroxyphenylalanine) and Dopamine (3, 4-Dihydroxy Phenyl Ethyl Amine) Using Electrochemical Methods[J].Journal of Rare Earths,2006,24(6):653-658. | |
| Authors: | Prashant N Trupti V Pathak Jignasu P Mehta G Ramchandraiha |
| Affiliation: | aDepartment of Chemistry, Bhavnagar University, Bhavnagar-364002, India bCentral Salt and Marine Chemical Research Institute, Waghavadi Road, Bhavnagar-364002, India |
| Abstract: | Eu (III) can be utilized as an indirect electrochemical probe to investigate the interaction of bio-molecules such as DOPA and Dopamine with Ca (II) in vitro. The interaction of DOPA and Dopamine with Eu(III)-Eu(II) redox pair was investigated by electrochemical techniques. Both the neurotransmitters are structurally related and undergo interaction with Eu (III). Eu (III) coordinates with DOPA and Dopamine through five-member chelate rings via carboxylic oxygen and amino nitrogen. The electrode kinetic parameters viz, transfer coefficient ( na), diffusion coefficient (D), forward heterogeneous rate constant (kofh) were evaluated for Eu(III)-DOPA/Eu(III)-Dopamine. The results obtained were used to investigate the nature of interaction of Eu (III) with multi-donor biomolecules. The possible mechanism was also proposed. |
| Keywords: | electrochemistry of Eu (III) chrono techniques electrochemistry of Eu (III)-neurotransmitters solution study rare earths |
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