液滴微流控的集成化放大方法研究进展

相比于传统乳化方法，液滴微流控技术可以在微通道内可控制备单分散液滴模板用于合成各种功能微球，被广泛应用于生物、医疗、制药、环境等领域。由于单个液滴制备微流控单元的产量低，液滴微流控的集成化放大成为了液滴微流控技术面向工业应用的技术难点。本文综述了近年来液滴微流控集成化放大方法的研究进展，重点介绍了不同类型液滴制备微流控单元集成化放大的研究进展，包括基于剪切力形成液滴、基于界面张力形成液滴和基于被动分裂形成液滴的液滴制备微流控单元的集成化放大方法。

Recent progress in scale-up integration of microfluidic droplet generators

Compared with conventional emulsification method, droplet microfluidics can controllably prepare monodisperse droplet templates in microchannels for synthesis of various functional microspheres, and is widely used in a lot of fields such as biological, medical, pharmaceutical and environmental engineering. Due to the low production rate of a single microfluidic droplet generator, scale-up integration of microfluidic droplet generators has become the technical difficulty to widespread utilization at the industrial scale. This paper reviews recent progress in scale-up integration of microfluidic droplet generators. Scale-up integration strategies for different types of microfluidic droplet generators, including droplet generators based on shear force, interfacial tension and passive break-up mechanisms, are mainly introduced.