Exercise Pretreatment Promotes Mitochondrial Dynamic Protein OPA1 Expression after Cerebral Ischemia in Rats |
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| Authors: | Li Zhang Zhijie He Qi Zhang Yi Wu Xiaojiao Yang Wenxiu Niu Yongshan Hu Jie Jia |
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| Affiliation: | 1.Department of Rehabilitation, Huashan Hospital, Fudan University, Shanghai 200040, China; E-Mails: (L.Z.); (Z.H.); (Q.Z.); (Y.W.); (X.Y.); (W.N.); (Y.H.);2.State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China |
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| Abstract: | Exercise training is a neuroprotective strategy in cerebral ischemic injury, but the underlying mechanisms are not yet clear. In the present study, we investigated the effects of treadmill exercise pretreatment on the expression of mitochondrial dynamic proteins. We examined the expression of OPA1/DLP1/MFF/Mfn1/Mfn2, which regulatesmitochondrial fusion and fission, and cytochrome C oxidase subunits (COX subunits), which regulatemitochondrial functions, after middle cerebral artery occlusion (MCAO) in rats. T2-weighted magnetic resonance imaging (MRI) was evaluated as indices of brain edema after ischemia as well. Treadmill training pretreatment increased the expression levels of OPA1 and COXII/III/IV and alleviated brain edema, indicating that exercise pretreatment provided neuroprotection in cerebral ischemic injury via the regulation of mitochondrial dynamics and functions. |
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| Keywords: | exercise pretreatment mitochondrial dynamics OPA1 cerebral ischemia neuroprotection |
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