| 抗菌肽偶联纳米银材料及其在医疗和食品领域的应用 |
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| 引用本文： | 谢闰生,李培骏,蒋羽秋,曹兴业,李海云,苏东林. 抗菌肽偶联纳米银材料及其在医疗和食品领域的应用[J]. 食品与机械, 2024, 40(5): 219-226 |
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| 作者姓名： | 谢闰生 李培骏 蒋羽秋 曹兴业 李海云 苏东林 |
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| 作者单位： | 桂林理工大学化学与生物工程学院，广西 桂林 541004；韶关学院广东省粤北食药资源利用与保护重点实验室，广东 韶关 512005;桂林理工大学化学与生物工程学院，广西 桂林 541004；韶关学院广东省粤北食药资源利用与保护重点实验室，广东 韶关 512005；韶关学院食品学院，广东 韶关 512005;湖南省农产品加工研究所，湖南 长沙 410125 |
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| 基金项目： | 国家重点研发计划项目（编号：2022YFD2100804）；韶关市支持科研工作者项目（编号：230324098034896）；韶关学院人才引进项目（编号：142-9900064701） |
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| 摘 要： | 由于具有抗菌活性，纳米粒子（NPs）和抗菌肽（AMPs）相结合可以用来杀死耐药（MDR）病原体。纳米银（AgNPs）具有广谱高效的抗菌性能、多种细菌灭活机制，并能对抗菌肽共轭银纳米粒子（AMP-AgNPs）表面进行共轭微调，使得AMP-AgNPs具有更高的生物安全性。文章综述了AMP-AgNPs偶联物的最新研究进展，讨论了AMP-AgNPs偶联物的合成方式、抗菌活性、作用机制、溶血毒性以及其在医疗和食品领域的应用，并对其未来发展方向进行了展望。
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| 关 键 词： | 细菌感染；抗菌肽；偶联物；生物安全性；医疗；食品 |
| 收稿时间： | 2024-02-27 |
Antimicrobial peptide-coupled silver nanomaterials and their applications in medical and food fields |
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| XIE Runsheng,LI Peijun,JIANG Yuqiu,CAO Xingye,LI Haiyun,SU Donglin. Antimicrobial peptide-coupled silver nanomaterials and their applications in medical and food fields[J]. Food and Machinery, 2024, 40(5): 219-226 |
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| Authors: | XIE Runsheng LI Peijun JIANG Yuqiu CAO Xingye LI Haiyun SU Donglin |
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| Affiliation: | College of Chemistry & Bioengineering, Guilin University of Technology, Guilin, Guangxi 541004, China;Provincial Key Laboratory for Utilization and Conservation of Food and Medicinal Resources in Northern Guangdong, Shaoguan University, Shaoguan, Guangdong 512005, China;College of Chemistry & Bioengineering, Guilin University of Technology, Guilin, Guangxi 541004, China;Provincial Key Laboratory for Utilization and Conservation of Food and Medicinal Resources in Northern Guangdong, Shaoguan University, Shaoguan, Guangdong 512005, China;College of Food Science & Technology, Shaoguan University, Shaoguan, Guangdong 512005, China; Hunan Agricultural Product Processing Institute, Changsha, Hunan 410125, China |
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| Abstract: | Due to antimicrobial activity, nanoparticles (NPs) in combination with antimicrobial peptides (AMPs) can be used to kill drug-resistant (MDR) pathogens. Nanosilver (AgNPs) has broad-spectrum and efficient antimicrobial properties, multiple bacterial inactivation mechanisms, and the ability to fine-tune the conjugation on the surface of antimicrobial peptide-conjugated silver nanoparticles (AMP-AgNPs), which results in higher biosafety of AMP-AgNPs. The review summarized the latest research progress of AMP-AgNPs conjugates and discussed the synthesis method, antibacterial activity, mechanism of action, hemolytic toxicity of AMP-AgNPs conjugates, as well as their applications in medical and food fields. The future development direction of AMP-AgNPs conjugates was also prospected. |
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| Keywords: | bacterial infection antimicrobial peptides coupling biosafety medical food |
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