Exacerbation of allergic inflammation in mice exposed to diesel exhaust particles prior to viral infection |
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| Authors: | Ilona Jaspers Patricia A Sheridan Wenli Zhang Luisa E Brighton Kelly D Chason Xiaoyang Hua Stephen L Tilley |
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| Affiliation: | (1) Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA;(2) Center for Environmental Medicine, Asthma, and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA;(3) Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA;(4) Department of Medicine, Division of Pulmonary and Critical Care Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA |
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| Abstract: | Background Viral infections and exposure to oxidant air pollutants are two of the most important inducers of asthma exacerbation. Our
previous studies have demonstrated that exposure to diesel exhaust increases the susceptibility to influenza virus infections
both in epithelial cells in vitro and in mice in vivo. Therefore, we examined whether in the setting of allergic asthma, exposure to oxidant air pollutants enhances the susceptibility
to respiratory virus infections, which in turn leads to increased virus-induced exacerbation of asthma. Ovalbumin-sensitized
(OVA) male C57BL/6 mice were instilled with diesel exhaust particles (DEP) or saline and 24 hours later infected with influenza
A/PR/8. Animals were sacrificed 24 hours post-infection and analyzed for markers of lung injury, allergic inflammation, and
pro-inflammatory cytokine production. |
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