New findings in the fatty acid composition of individual platelet phospholipids in man after dietary fish oil supplementation |
| |
Authors: | Trevor A Mori James P Codde Robert Vandongen Lawrence J Beilin |
| |
Affiliation: | (1) Department of Medicine, University of Western Australia, Royal Perth Hospital, 6000 Perth, Western Australia |
| |
Abstract: | Nine healthy male volunteers were given 15 Max EPA fish oil capsules providing 2.67 g of eicosapentaenoic acid (EPA, 20∶5ω3)
and 1.72 g of docosahexaenoic acid (DHA, 22∶6ω3) daily for 3 wk. Measurements were taken at baseline, at the end of the fish-oil
period, and at 2 and 6 wk postsupplementation. The effect of fish oil on plasma lipids and the fatty acid composition of individual
platelet phospholipids was studied. In general, the proportions of 20∶5ω3 and 22∶6ω3 in platelet phosphoglycerides were substantially
increased mainly at the expense of arachidonic acid (AA, 20∶4ω6). A large and significant increase in the relative EPA content
of phosphatidylcholine (PC) (P<0.001) and phosphatidylethanolamine (PE) (P<0.001) was noted at the end of the 3 wk supplementation.
We have also shown for the first time a small but significant (P<0.001) incorporation of EPA in phosphatidylserine (PS). Incorporation
of DHA was also detected in PC, PE and PS, whereas the relative AA content of these phospholipids was significantly reduced.
Fish oil supplementation led to a significant increase of 22∶5ω3 in PS and decreases of 20∶3ω6 in PC and 22∶4ω6 in PE. Postsupplementation
measurements showed a gradual return of all fatty acids to baseline levels. The fatty acid composition of the phosphatidylinositol
(PI) fraction remained unchanged throughout the trial period. We conclude that in humans ω3 fatty acids are incorporated into
platelet membrane phospholipid subclasses with a high degree of specificity. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|