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| Synthesis and Characterization of a Biodegradable Copolymer: RGD Peptide Modification of Poly (lactic acid-co-lysine) | |
| 引用本文： | 李红,段友容. Synthesis and Characterization of a Biodegradable Copolymer: RGD Peptide Modification of Poly (lactic acid-co-lysine)[J]. 武汉理工大学学报(材料科学英文版), 2005, 20(Z1) |
| 作者姓名： | 李红 段友容 |
| 作者单位： | Shanghai Cancer Institute Shanghai Jiaotong University Shanghai 200032 China，Shanghai Cancer Institute Shanghai Jiaotong University Shanghai 200032 China，State Key Laboratory for Modification of Chemical Fibers and Polymer Material，Donghua University Shanghai 200051 China |
| 基金项目： | FundedbytheShanghaiNaturalScienceFoundation(No.04zr14008) |
| 摘 要： | 1Introduction Theuseofsyntheticdegradablepolymersindrugde liverysystemshasdramaticallyexpandedinthepastde cade.Poly(glycolicacid),poly(lacticacid),andtheir copolymersaresyntheticpolyestersthathavebeenap provedbytheFDAforcertainusesandinvestigatedfor manya… |
Synthesis and Characterization of a Biodegradable Copolymer: RGD Peptide Modification of Poly (lactic acid-co-lysine) |
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| Abstract: | The poly (lactic acid-co-lysine) was synthesized using IR and 1H NMR to characterize the copolymer. And then the RGD modification copolymer RGD-PLAL was prepared. The contact angles were used to see the RGD modification occurrence. Also high molecular weight polymer was controlled to the reaction of polymerization of copolymer. |
| Keywords: | RGD ring opening PLAL drug delivery |
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