Adhesion to laminin is down-regulated upon retinoic acid-induced F9 cell differentiation: a role for alpha 6/beta 1 integrin |
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| Authors: | MC Elias R Chammas RR Giorgi F Frochtengarten CL Santos RR Brentani |
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| Affiliation: | Instituto Ludwig de Pesquisa sobre o Cancer, S?o Paulo, Brasil. |
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| Abstract: | F9 mouse teratocarcinoma cells have a high capacity to adhere to laminin and we identified alpha 6/beta 1 integrin as the principal laminin-binding protein present in these cells. F9 cells differentiated into parietal endoderm when monolayer cultures were treated with retinoic acid and dibutyryl cyclic AMP. In this process a decreased adherence to laminin was observed due to a lower expression of alpha 6/beta 1 integrin on the cell surface. |
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