Influenza virus hemagglutinin stimulates the protein kinase C activity of human polymorphonuclear leucocytes |
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| Authors: | DJ Arora N Gasse |
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| Affiliation: | Virology Research Center, Institut Armand-Frappier, Laval, Québec, Canada. |
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| Abstract: | Human polymorphonuclear leukocytes (PMNL) incubated with influenza virus, A/USSR/90/77 (H1N1) or its hemagglutinin produced a significant increase in their PKC activity when compared with untreated PMNL. The activated kinase translocated from cytosol to cellular membrane. The calcium-dependent enzyme activity was inhibited by a specific inhibitor suggesting that alpha and/or beta isoforms of PKC were involved. |
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