Subcellular localization of Bcl-2 protein in synovial sarcoma |
| |
Authors: | S Kawauchi S Noguchi T Fukuda M Tsuneyoshi |
| |
Affiliation: | Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan. |
| |
Abstract: | The subcellular localization of Bcl-2 protein in surgically resected, fixed-frozen tissue specimens of seven tumors from six cases of synovial sarcoma and a synovial sarcoma cell line was examined using laser-scanning confocal microscopy and immunoelectron microscopy. Bcl-2 protein in synovial sarcoma cells was detected in the nuclear envelope, endoplasmic reticulum membrane, and mitochondrial circumference. Based on the finding of pre-embedding immunoelectron-microscopy observation, the distribution of Bcl-2 protein in such membranous organella was patchy. A computer-based image analysis failed to reveal any quantitative differences between the inner and the outer mitochondrial membranes. The tumorigenesis of synovial sarcoma is also discussed from the viewpoint of Bcl-2 overexpression. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|