微反应器内基于氮氧自由基催化剂连续氧气/空气氧化反应的研究进展

连续液相氧气氧化技术代替传统氧化技术已经成为氧化反应发展的一大趋势。但是，分子氧通常需要被合适的催化剂进行活化后才能进行高选择性氧化。近年来，氮氧自由基催化剂因其能够在温和条件下高效地催化氧气氧化反应而取得了快速发展。此外，可持续的绿色氧化工艺不仅依赖于高效环保的催化体系，还需要依托能够强化传质和反应性能的反应器技术。本文介绍了连续微反应氧化技术中常用的微反应器，归纳总结了以氮氧自由基及其衍生物为催化剂的空气/氧气氧化反应在连续有机合成中的研究进展。最后，针对现阶段氮氧自由基催化的连续液相氧化技术的潜在挑战，对该技术在精细化工领域中的应用进行了展望。

Advances in continuous aerobic oxidation based on nitroxyl radical catalyst in microreactors

The replacement of traditional oxidation technology by continuous liquid-phase aerobic oxidation technology has become a major trend in the development of oxidation reactions. However, molecular oxygen usually needs to be activated by a suitable catalyst system for highly selective oxidation. In recent years, nitroxyl radical catalysts have achieved rapid development due to their ability to efficiently catalyze aerobic oxidation under mild conditions. In addition, sustainable green oxidation processes not only rely on efficient and environmentally friendly catalytic systems, but also on reactor technologies that can enhance mass transfer and reaction performance. This paper introduces the commonly used microreactors and summarizes the research progress of aerobic oxidation reaction in continuous organic synthesis using nitroxide radicals or their derivatives as catalysts. Finally, in view of the potential challenges of the continuous liquid-phase oxidation technology catalyzed by nitrogen oxide radicals at this stage, a prospect for the future application of this technology in the field of fine chemicals is put forward.