基于近红外图像处理的便携式干眼诊断仪研究

针对目前市面上的干眼诊断设备有诸如成本高、体积大和由于使用帧差法导致检测结果准确度不高等一些问题，本文设计了基于近红外图像诊断干眼的便携式设备。该设备使用基于近红外成像的Windows计算机进行检测，便于携带，可用于检测泪膜破裂时间（tear film break-up time, TBUT）、睑板腺（meibomian gland, MG）与泪河高度（tear meniscus height, TMH）等干眼症状。采用分形盒维数法检测TBUT，避免帧差法检测不准确；通过近红外（850 nm）补光成像技术检测MG，采用对比度受限自适应直方图均衡（contrast-limited adaptive histogram equalization, CLAHE）算法处理，将腺体区域突出，能够更加准确地检测面积缺失率。为了验证该仪器检测结果准确性，使用50组测试样本进行验证性实验，实验结果与意大利的CSO Antares（安达斯）仪器和SBM公司的ICP OSA等的检测结果进行对比。该设备的TBUT和TMH检测的结果与两个对照组结果的相关系数为P < 0.05，检测的结果一致性较好；MG的检测正确率为86%，特异度为84%。实验结果表明，该设备可作为干眼症的筛查和诊断设备用于眼科医院和视觉光学中心。

Portable Dry Eye Diagnosis Instrument Using Near-infrared Image Procession

To address the limitations of current dry eye diagnostic equipment in the market, such as high cost, large volume, and low accuracy of detection results due to the use of the frame difference method, this study proposes portable dry eye diagnostic equipment based on near-infrared images. The device, which uses a Windows computer based on near-infrared imaging, is portable and can be used to detect dry eye symptoms such as the tear film break-up time (TBUT), meibomian gland (MG), and tear meniscus height (TMH). The fractal box dimension method was used to detect TBUT to avoid the inaccuracy of the frame difference method. MG was detected using near-infrared (850 nm) fill light imaging technology, and the contrast limited adaptive histogram equalization (CLAHE) algorithm was used to highlight the gland region, which can detect the area missing rate more accurately. To verify the accuracy of the test results, 50 samples were tested and compared with the CSO Antares instrument from Italy and the ICP OSA from SBM. The correlation coefficient between the TBUT and TMH measurements of the device and the results of the two controls was P < 0.05, whereas the detection results were consistent; the accuracy and specificity of MG were 86% and 84%, respectively. The experimental results showed that the device can be used as a screening and diagnostic device for dry eye disease in eye and vision optics centers.